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023) as compared to the standard of care during the first two hours of use. No complications or iatrogenic injury were identified in any animal for either device. The novel PPTS device was superior to the traditional chest tube drainage system in this acute, large-animal model of retained hemothorax. While this study supports clinical translation, further research will be required to assess efficacy and optimize device use in humans. The novel PPTS device was superior to the traditional chest tube drainage system in this acute, large-an