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The optimum 3DP tablet shows significantly higher dissolution than Inovelon® at the therapeutic dose due to its improved wdissolution.Ethnopharmacological relevance Yuk-Mi-Jihwang-Tang (YJT) has been popularly prescribed to treat aging related disorders over than hundreds of years in East Asia countries. Aim of the study To investigate possible modulatory actions of YJT on chronic restraint stress (CRS)-induced neurodegeneration on hippocampus neuronal injuries. Materials and methods Mice were orally administered with YJT (100, 200, or