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Results IR regularization strength influenced CAC scores significantly ( p less then 0.05 ). The CAC volumes and scores between FBP and IRs were the most similar when the IR regularization strength was chosen to match the MTF of the FBP reconstruction. Conclusion When the regularization strength is selected to produce comparable spatial resolution with FBP, IR can yield comparable CAC scores and volumes with FBP. Nonetheless, at the lowest radiation dose setting, FBP produced more accurate CAC volumes and scores compared to IR, and no im
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