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OBJECTIVES With the acceleration of the process of aging population, to enjoy a higher health-related quality of life (HRQoL) is the goal of the elderly population and public health. Studies on relationship between HRQoL and lipid profile through a large sample of representative elderly population are scare. OBJECTIVE This study was conducted to firstly explore the relationships of lipid profile with HRQoL in Chinese centenarian population. PARTICIPANTS A complete sample of 1002 participants aged over 100 years from Hainan province were recruited in the cur