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clinicians quickly identify high-risk patients and make appropriate medical decisions. Using a simple and effective risk assessment model can help clinicians quickly identify high-risk patients and make appropriate medical decisions. Increasing number of studies provide evidence that the vagus nerve stimulation (VNS) dampens inflammation in peripheral visceral organs. However, the effects of afferent fibers of the vagus nerve (AFVN) on anti-inflammation have not been clearly defined. Here, we investigate whether AFVN are involved in VNS