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Specifically, healthy controls (n=2 were most likely to have negative IGRA results (67.09%), whilst 27.27% of active cases (n=33) and 3.85% of quiescent cases (n=26) had indeterminate results (p=0.02). The number of immunosuppressant therapies was significantly negatively correlated with IFN-γ (p=0.004). No difference in IFN-γ concentration was detected amongst the active and other groups (p0.05). High-activity SLE and immunosuppressive therapies cause dysregulation of the immune response, which, in turn, influences IGRA results.
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