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Games-based drills (GBD) are the predominant form of training stimulus prescribed to male and female basketball players. Despite being readily manipulated during GBD, the impact of defensive strategy on the sex-specific demands of GBD remains unknown. Therefore, the aim of this study was to quantify and compare the heart-rate (HR) responses experienced during 5v5 GBD using different defensive strategies (man-to-man defense vs zone defense [ZD] formations) according to player sex. HR was recorded in 11 professional male and 10 professiona