https://www.selleckchem.com/pr....oducts/pirtobrutinib
BACKGROUND Precipitated opioid withdrawal (POW) after opioid antagonist administration can be challenging to manage in the emergency department (ED), particularly if caused by a long-acting opioid antagonist such as naltrexone. There are no evidence-based guidelines to assist in safely and efficiently managing patients with this syndrome. OBJECTIVE OF REVIEW To review current practice on the treatment of long-acting antagonist POW and make recommendations on the treatment of this complex disease process. METHODS A literat