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Single-nucleotide polymorphisms (SNPs) in FSHB and FSHR genes have been described, some of them impacting testicular volume and sperm output. The FSHR p.N680S and the FSHB -211GT variants could be genetic marker to predict FSH response. CONCLUSIONS FSH may be helpful to increase sperm production in infertile men, even if the evidence to recommend the use of FSH in this setting is weak. Placebo-controlled clinical trials, considering FSHB-FSHR haplotype, are needed to define the most effective dosage, the best treatment length and th