https://www.selleckchem.com/pr....oducts/l-kynurenine.
Delayed methotrexate (MTX) elimination after treatment with high-dose (HD) MTX may result in life-threatening toxicities as well as acute kidney injury. Treatment includes administration of glucarpidase, an enzyme that rapidly inactivates MTX. Dosing of glucarpidase is based on body weight; however, recommendations for dosage adjustments in obese patients are lacking. We describe three obese adult patients (BMI range 31-43 kg/m2 ) who received HD-MTX following all precautions for the treatment of HD-MTX. Although peak MTX concentra
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