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a la variabilidad en la respuesta patológica. Identificar a los pacientes con OAC que obtendrían el mayor beneficio de la NAC debería centrar el foco de atención.Pathogen-mediated balancing selection is commonly considered to play an important role in the maintenance of genetic diversity, in particular in immune genes. However, there has not been any systematic analysis of what factors influence which immune genes are the targets of such selection. To address this, we here focus on Pattern Recognition Receptor (PRR) signalling pathways,