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Clinical studies suggest altered systemic vascular biology in cancer patients. We assessed expression patterns of endothelial activation- and vascular leakage-related genes in tumor as well as in tumor-free peripheral tissues from patients with and without ovarian cancer (OC). Patients being scheduled for laparotomy for either gynecologic benign diagnosis (n=1 or for advanced-stage OC (n=22) were prospectively recruited to this observational study. Serum samples were taken preoperatively, and tissue samples were taken from peripheral a
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