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The prevalence of chemsex has-been reported by multiple systematic reviews among men who've sex with males (MSM) focussing predominantly from the Global North. An Asian viewpoint with meta-analytical research is missing. This meta-analysis summarised the prevalence of substance usage related to chemsex, and chemsex activity among MSM and MSM sub-populations in Asia, as well as the probability for chemsex among MSM living with or without HIV. We identified 219 researches and included 23 in the meta-a