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To report a case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection 6months after the first infection in a young healthy female physician. Both episodes led to mild coronavirus disease 2019 (COVID-19). SARS-CoV-2 infections were detected by real-time reverse transcriptase PCR (RT-PCR) on nasopharyngeal specimens. Reinfection was confirmed by whole-genome sequencing. Kinetics of total anti-S receptor binding domain immunoglobulins (Ig anti-S RBD), anti-nucleoprotein (anti-N) and neutralizing antibodies were determi