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s of bipolar disorder is important, but over-diagnosis risks adverse iatrogenic consequences. Bipolar disorder is very rare in childhood and rare in adolescence. PBD as a diagnostic construct fails to correlate with adult bipolar disorder and the term should be abandoned. Hypomanic syndromes in adolescence may not always progress to adult bipolar disorder. Early diagnosis of bipolar disorder is important, but over-diagnosis risks adverse iatrogenic consequences.This study tested bidirectional relations between infant high-intensity fear