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. Subpatent infections were associated with increased LBW and preterm delivery. More sensitive diagnostic tests are needed to detect and treat low-grade infections. Centers for Disease Control and Prevention and Worldwide Antimalarial Resistance Network. Centers for Disease Control and Prevention and Worldwide Antimalarial Resistance Network.Background Randomized clinical trials (RCTs) of anticancer drugs without active comparators in patients who have exhausted standard of care treatment options are debated. We aimed to quantify the safety and th