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01, 95% CI [-0.02, 0.01]) on mental health. We found evidence that self-esteem mediates the impact that both clinical seizure burden and peer support have on mental health outcomes, indicating that assessment of and interventions targeting self-esteem may be appropriate for young people with epilepsy. Supporting self-esteem could mitigate negative influences on mental health, whether from resistant epilepsy or low peer support. We found evidence that self-esteem mediates the impact that both clinical seizure burden and peer support have