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61; 95 % confidence interval [CI], 1.35-1.91) and incident CVD event (HR, 1.45; 95 % CI, 1.16-1.82). Additionally, participants with ≥3 high-variability components had increased odds of arterial stiffness, as measured by brachia-ankle pulse wave velocity (odds ratio [OR], 1.39; 95 % CI, 1.19-1.63). Our findings suggest that participants with at least three metabolic parameters with high variability experienced increased risk of CVD and all-cause mortality. Our findings suggest that participants with at least thr