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Conclusion The obtained results based on the temperature gradient changes in the lesion vicinity area may bring some new information describing the range of biochemical and physiological processes occurring during photodynamic therapy.Abstract.History A 58-year-old man presented with refractory hypokalemia and rapid weight gain. On examination, he had high blood pressure, central obesity and bilateral pitting edema. Findings and diagnosis Biochemical tests showed hypokalemic metabolic alkalosis due to ACTH-dependent hypercortisolism. C