https://www.selleckchem.com/pr....oducts/CI-1040-(PD18
0331, Padj=0.0015) and a similar trend in the replication sample (significant before multiple comparison adjustment). The association of longevity-PRS with WMH remained significant after removing the influence of the apolipoprotein E locus (whole WMH, β=-0.0297, Padj=0.0048). While total grey matter and cortical volumes were related to parental lifespan in the discovery sample, they were not significantly associated with longevity-PRS. Additionally, the effects of longevity-PRS on the association were more prominent in males.
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