https://www.selleckchem.com/pr....oducts/BI6727-Volase
We found that the presence of four parallel pathways leads to a 2.5-fold acceleration in folding; that is, the effective folding rate from the unfolded to folded ensembles is 2.5 times as large as the rate constant for the fastest individual pathway. Since many G4 sequences can adopt many more than four isomers, folding accelerations of more than an order of magnitude are possible via this mechanism. Historically, symptomatic, benign intradural extramedullary (IDEM) spine tumors have been managed with surgical resection. Howev
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