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In this paper, we report about the miniaturized and thin wireless wearable percutaneous arterial oxygen saturation (SpO2) sensor module with bendable build-up substrate. As one of an effective approach for miniaturizing and thinning a wearable device, there is a method of applying the folding structure to the module. In order to realize folding structure, we have studied bending characteristics of the bendable build-up substrate and considered for wearable application. In addition, we developed the SpO2 sensor module with folding structu