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Bidirectional irrigation system decreases secondary infections and complications, and increases the healing rate in patients with difficult wound. Bidirectional irrigation system decreases secondary infections and complications, and increases the healing rate in patients with difficult wound.Crocin is the main monomer of saffron, which is a momentous component of traditional Chinese medicine Lang Qing A Ta. Here, we tried to probe into the role of crocin in liver fibrosis. Hematoxylin-eosin staining and Sirius Red staining were used to o