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tients with T0-FLR 30%. NTL-Dmean and NTL exposed to ≥ 30 Gy (NTL-V3 were most significantly associated with increase in FLR (particularly among patients with T0-FLR less then 30%). When half of NTL received ≥ 30 Gy, FLR increased to ≥ 40%, with higher accuracy among patients with T0-FLR less then 30%.Normal brain aging is commonly associated with neural activity alteration, β-amyloid (Aβ) deposition, and tau aggregation, driving a progressive cognitive decline in normal elderly individuals. Positron emission tomography (PET) with