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In mice, intraperitoneal management of chlorpromazine paid down indigenous CaV currents' sensitivity to ω-conotoxin-GVIA and their particular dimensions by ∼49% in level V/VI pyramidal neurons from medial PFC, showing a selective effect on CaV2.2. Also, we unearthed that reducing D1/D5R constitutive activity correlates with a decrease in the agonist-induced D1/D5R inhibitory influence on local CaV currents. Our outcomes might be interpreted as a stimulatory aftereffect of D1R constitutive a