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05). After the PDGF-D gene was silenced, the growth and colony forming abilitys ignificantly decreased (P.05) together with the induction of apoptosis in MDA-MB-231 cells (P.05). Moreover, MDA-MB-231 cells with PDGF-D silencing showed significantly diminished aggressive migration and invasion potential compared to other cells (P.05). In vivo experiments also indicated that PDGF-D silencing inhibited tumor growth and improved the survival rate of tumor-bearing mice. Downregulation of PDGF-D had dramatic effects on breast canc
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