https://www.selleckchem.com/pr....oducts/glumetinib.ht
Mechanistically, Sag transgenic expression altered several key signaling pathways, particularly inactivation of mTORC1 signaling due to Deptor accumulation, and activation of the antioxidant Nrf2-Nqo1 axis. Thus, Sag plays a stage dependent promotion (early) and fate-changing (late) role during Kras-pancreatic tumorigenesis, likely via regulating its key substrates, which control growth-related signal transduction pathways. Neuroblastoma is an aggressive pediatric malignancy of the neural crest with suboptimal cure rates and a striki
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