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Hypophysitis, which is frequently associated with pituitary disorder, is classified into several subtypes on the basis of the cause, histology, and the location of irritation into the pituitary gland. A definitive diagnosis needs pituitary biopsy, which is unpleasant, in addition to process is restricted to specific clinical options. In this viewpoint paper, we examine the literary works associated with hypophysitis, and offer the principles associated with Japan Endocrine Society for