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INTRODUCTION Cutaneous adverse events (AE) are the most prevalent toxicity under checkpoint-inhibitors in clinical trials. In "real-life" conditions of use, skin toxicities under anti-PD-1 have not been described to date in a large cohort. The objective of this study was to determine the clinical features of skin toxicities in patients with advanced melanoma receiving anti-PD-1 therapy under "real-life"-conditions of use. Secondary objectives were to evaluate the characteristics of patients with skin toxicities and to analyze associated extra-cutaneous toxi