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Significant heterogeneity was identified both among customers and between pre- and posttreatment samples. PIK3CA has got the potential becoming a predictive biomarker. To help assess the ramifications of a treatment related modified PIK3CA mutation profile, more information are required.Considerable heterogeneity was identified both among clients and between pre- and posttreatment examples. PIK3CA has got the prospective becoming a predictive biomarker. To further assess the imp