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The risk factors of PTE were male (HR = 1.6, 95% CI 1.1-2.2, P = 0.009), early posttraumatic seizures (HR = 2.9, 95% CI 2.2-4.1, P 24 h HR = 2.4, 95% CI 1.4-2.4, P = 0.001), subdural hematoma (SDH) (HR = 1.9, 95% CI 1.4-2.5, P less then 0.001), brain contusion sites (frontal-temporal lobe HR = 2.7, 95% CI 1.9-3.9, P less then 0.001; other sites HR = 1.5, 95% CI 1.01-2.3, P = 0.042) and cranial surgery (HR = 1.7, 95% CI 1.3-2.3, P less then 0.001). Significance The probability of developing PTE increased during the s