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We report the results of a single-institution, prospective stage 2 test of myeloablative haploBMT using busulfan-based or total body irradiation-based conditioning in 96 children or grownups (median age, 42 years; range, 1-65 years) with high-risk hematologic malignancies. Recovery of neutrophils and platelets took place at a median of 24 and 29 times. Engraftment of donor cells with chimerism 95% was attained in 91%. The cumulative incidence of severe graft-versus-host illn