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Pharmaceutical products are widely consumed globally and are commonly found in wastewaters as a result of constant excretion and disposal into sewers. The present study proposes an efficient binary solvent dispersive liquid-liquid microextraction (BS-DLLME) method that was developed for preconcentration of 7 nervous system drug active compounds from aqueous media for their determination at trace levels by gas chromatography-mass spectrometry. The drug analytes included 3 antidepressants, 2 antipsychotics, 1 antiepileptic, and 1 antidemen