https://www.selleckchem.com/pr....oducts/abc294640.htm
Initially developed to generate new treatments for epilepsy, gabapentin, and pregabalin ("gabapentinoids" were engineered to mimic the action of GABA and to modulate GABA metabolism. Rather than their intended pharmacological action on GABA neurotransmission, instead, they exhibit a high affinity for the α2δ-1 and α2δ-2 subunits of voltage-activated calcium channels, wherein binding of gabapentinoids inhibits cellular calcium influx and attenuates neurotransmission. Despite a lack of activity on GABA levels, gabapentin and pregabalin
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