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Of course, protected checkpoints get additional attention in this book. There are lots of typical pathways which are involved with signaling various checkpoints. Many of them are integrated and provided as common activities in the early section of this chapter, especially those involving PD-1/PD-L1 and CTLA-4, because investigations regarding them are especially abundant and variant. Their particular distinct regulation is supplementarily talked about inside their particular area. As for checkpoints that are so fa