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Tropical marine habitat-builders such as calcifying green algae can be susceptible to climate change (warming and acidification). This study evaluated the cumulative effects of ocean warming (OW), ocean acidification (OA) and the herbicide diuron on the calcifying green algae Halimeda opuntia. We also assessed the influence of acclimation history to experimental climate change conditions on physiological responses. #link# H. opuntia were exposed for 15 days to orthogonal combinations of three climate scenarios [ambient (28 °C, pCO2 = 37