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Background We aimed to evaluate the association between the vascular endothelial growth factor (VEGF) gene +936CT polymorphism and digestive system tumors using a meta-analysis. Methods Studies of the association between the VEGF+936CT polymorphism and digestive system tumors published before December 2019 were searched in PubMed, EMBASE, Web of Sciences, the Chinese Biological and Medical Database (CBM), and the China National Knowledge Infrastructure (CNKI). The odds ratio and the corresponding 95% confidence interval were use