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miR-1258 regulates the proliferation and cell cycle to inhibit the progression of BC by targeting and downregulating E2F1. miR-1258 regulates the proliferation and cell cycle to inhibit the progression of BC by targeting and downregulating E2F1. Globally, prolonged and obstructed labors were among the common causes of maternal morbidity and mortality in low- and middle-income countries including Ethiopia. The World Health Organization (WHO) recommends the routine use of partograph as a key intervention to avoid prolonged and obstructed