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In inclusion, menthol has actually essential pharmacological impacts and it is effective against a wide variety of organisms. The development of prodrugs allows improving the pharmacokinetic properties of the parental drug. To improve lipophilicity and therefore the bioavailability of menthol, a novel prodrug called menthol-pentanol was created by masking the useful polar number of menthol by connecting n-pentanol by a carbonate bond. The aim of the present work would be to measure the in v