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Obesity-hypoventilation syndrome occurs with alveolar hypoventilation during sleeping and daytime. Obesitymay be ariskfactor for venous thromboembolism. However, the venous thromboembolism in the obesity-hypoventilation syndrome is not well characterized. This case series aimed to investigate the presence and clinical features of venous thromboembolism in patients with the obesity-hypoventilation syndrome. Data of eight case reports were collected. Ages ranged from 36 to 73 years. All patients had mosaic perfusion and enlarged main pulm