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ADHD Medications For Adults Stimulants aid in adjusting the levels of chemical messengers in the brain that control attention. They are considered to be the first-line medication for treating ADHD. They aren't believed to be a habit-forming drug, but they can have negative side effects, including headaches and difficulty sleeping. Your doctor may prescribe Guanfacine (brand names Tenex and Intuniv) or Clonidine (Catapres) to decrease hyperactivity and impulsivity. are longer-acting