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ADHD Treatment Medication Adults with ADHD are usually treated with psychosocial therapy and medications. The drugs used to treat ADHD can include stimulants as well as nonstimulants. Stimulants like methylphenidate and lisdexamfetamine act on chemical messengers in the brain to improve concentration, mood and control of impulses. Atomoxetine, or guanfacine which are non-stimulant ADHD drugs, are prescribed to teens, adults or children who are not responsive to stimulants. Stim