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ADHD in Adults - Treatment Options ADHD is a well-known neurobiological disorder that affects 4.4% of the general population. It is associated with high rates of comorbidity, including depression, anxiety and substance abuse and significant emotional, social and occupational impairments. Medications and psychotherapy are both effective treatments for adults with ADHD. The most commonly prescribed medications are stimulants, such as methylphenidate and amphetamine. Medicines Many adults with ADHD report significant improvements in their symptoms as well as fu