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The MD simulations analysis provided new insights into the TIGIT/PVR interaction model, and the identified PVR mutants ( S72W, S72R, G131V and S132Q) could serve as new candidates for immunotherapy to block TIGIT/PVR. Video Abstract. The MD simulations analysis provided new insights into the TIGIT/PVR interaction model, and the identified PVR mutants (PVRS72W, PVRS72R, PVRG131V and PVRS132Q) could serve as new candidates for immunotherapy to block TIGIT/PVR. Video Abstract. Copy number variation (CNV) suggests genetic changes in malignant tumors. Abnormal e
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