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Of those, 58 clients created distant metastases (DM) and 29 created isolated local recurrence (ILR) due to the fact first indication of disease relapse. All patients with CTCs experienced DM. pN-status and histological grade 2 were other separate danger elements for DM, but only CTCs predicted significantly reduced cancer-specific, disease-free and post-recurrence survival. Preoperative variables did not affect clinical outcome. We conclude that CTC presence i