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Health Issues That Affect German Shepherd Life Expectancy German Shepherds reach their peak between the ages of 2 and 6. They're at their strongest in terms of physical fitness and mental toughness. They are more at risk for cancer, musculoskeletal problems, and other health conditions that can affect their lifespan. German Shepherds in the working line usually lead more active lives than their show line counterparts. They require a nutrient-rich diet to help them meet their high activity levels