https://www.selleckchem.com/pr....oducts/sirpiglenasta
Systematic comparison of analysis methods of clinical microdialysis data for impact on target-site drug exposure and response. 39 individuals received a 500mg levofloxacin short-term infusion followed by 24-h dense sampling in plasma and microdialysate collection in interstitial space fluid (ISF). ISF concentrations were leveraged using non-compartmental (NCA) and compartmental analysis (CA) via (ii) relative recovery correction at midpoint of the collection interval (midpoint-NCA, midpoint-CA) and (ii) dialysate-based integrals
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