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evere infections (aOR 0.27, 95% CI 0.17-0.42) compared to those who never smoked. Current smoking was negatively associated with SARS-CoV-2 infection with a dose-dependent relationship. Ad hoc experimental studies are needed to elucidate the mechanisms underlying this association. ClinicalTrials.gov NCT04471701; https//clinicaltrials.gov/ct2/show/NCT04471701. ClinicalTrials.gov NCT04471701; https//clinicaltrials.gov/ct2/show/NCT04471701.Histone deacetylases (HDACs) are a family of enzymes that modulate the acetylation status histones an
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