https://www.selleckchem.com/products/vx-11e.html
High-dose valproic acid (VPA) improves the survival and neurologic outcomes after asphyxial cardiac arrest (CA) in rats. We characterized the pharmacokinetics, pharmacodynamics, and safety of high-dose VPA in a swine CA model to advance clinical translation. After 8min of untreated ventricular fibrillation CA, 20 male Yorkshire swine were resuscitated until return of spontaneous circulation (ROSC). They were block randomized to receive placebo, 75mg/kg, 150mg/kg, or 300mg/kg VPA as 90-min intravenous infusion (n=5/group) beginning at ROS
Like
Comment
Share
