https://www.selleckchem.com/pr....oducts/rxdx-106-cep-
Flavopiridol and JQ1 inhibitors act synergistically, and a combination of both almost completely prevented the activation of most IL-1β-induced PRGs in vitro by microarray analysis, and prevented IL-1β-induced glycosaminoglycan release from cartilage explants. Mice given the drug combination showed reduced IL-1β and IL-6 expression, less in vivo MMP activity, and lower synovitis (1.5 vs 4.9) and OARSI scores (2.8 vs 6. than untreated mice with ACL-rupture. JQ1 and Flavopiridol work synergistically to reduce injury response
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